About the evidence-based method of diagnosis of celiac disease

About the evidence-based method of diagnosis of celiac disease

On October 27, 2022, an offline-online conference was held at UH of SMU, NCJSC with the participation of teachers of the Department of Pediatrics and Medical Rehabilitation named after D. M. Tusupova, the Department of Propaedeutics of Children’s Diseases, pediatricians of the pediatric department, resident pediatricians of the 1st, 2nd years of study in Semey and Ust-Kamenogorsk on the topic: “Diagnosis of celiac disease (gluten enteropathy)”.

Celiac disease is a disease associated with intolerance to gluten protein, which disrupts the functioning of the mucous membrane of the small intestine. There is an intolerance to one of the protein fractions, namely gliadin. The cause is considered to be a defect in the immune system, due to which a pathological reaction to gluten occurs. It consists in the formation of antibodies (protective proteins) against the cells of the mucous membrane, where gluten absorption should normally be carried out. Genetic factors also play a role in the development of the disease. A defect in the genes located on the 6th chromosome may contribute to a pathological immune response to gluten.

Samrun specialist in autoimmune diagnostics Ainur Dosmagul elaborated on modern protocols for the diagnosis of celiac disease from the standpoint of evidence-based medicine. One of the evidence-based diagnostic methods is the Gastro 5 LINE Immunoblot for the determination of IgG and/or IgA antibodies to: deamidated gliadin, tissue transglutaminase, internal factor (Castle factor), yeast mannan parietal cell antigens (Saccharomyces cerevisiae). This is the latest method in which antibody levels can be determined very quickly and conveniently and autoimmune diseases can be diagnosed. Such diagnostics is already actively used in large cities of Kazakhstan and has demonstrated its effectiveness.

The opening of such a laboratory in Semey on the basis of UH of SMU, NCJSC would allow doctors to timely diagnose and treat autoimmune diseases (celiac disease, Crohn’s disease, etc.) in children and adults of our region on the spot, without referral to the leading centers of Almaty and Astana.