In the KGP at the RPV “Polyclinic No. 1 of the city of Semey”, UZ OA on September 19, 2023, by a dermatovenerologist, Ph.D. Professor RAE Adilgozhina S.M. а master class was held among general practitioners and residents of the 2nd year of study in the specialty of family medicine on the topic: “Choosing the first biological medication is an important step towards remission of psoriasis.” Damage to exposed skin areas affects the emotional state and psychological status of patients with psoriasis, influencing the choice of clothing, profession, daily and professional activities, causing the development of vegetoneurotic and psychosocial disorders during the period of exacerbation of the disease, such as increased anxiety, low self-esteem, social maladaptation, depression. The main goal of treatment for patients with psoriasis is the indicator “clear/almost clear skin”. The issues of management of “bionaive” patients, various factors influencing the likelihood of patients’ response to GEBD therapy and the important role of biological drugs in the treatment strategy of patients were considered. Physicians and residents were trained using the ONE PRESS auto-injector to perform self-injection of biologically active drugs.