History of the Department
The Department was established in 1996. From 1996 to 2018, the Head of the Department of Internal Diseases №2, and later the Department of Internship in Therapy, was Doctor of Medical Sciences, Professor, and Corresponding Member of the Academy of Medical Sciences of the Republic of Kazakhstan, Lyudmila Kusainovna Karazhanova.
From 2018 to 2021, due to university reorganization, the department was divided into two structural units: the Department of Hospital Therapy and the Department of Cardiology and Interventional Arrhythmology, headed by Professor Karazhanova’s students — PhD A. N. Zhumagalieva and Candidate of Medical Sciences, Associate Professor E. I. Yesimbekova.
In 2022, as a result of further restructuring, the Department of Therapy was established, headed by PhD, Associate Professor D. A. Mansurova.
The teaching staff consists of highly qualified specialists with extensive clinical and teaching experience, including Doctor of Medical Sciences, Professor L. K. Karazhanova, Doctor of Medical Sciences, Professor M. Zh. Espenbetova, and Candidate of Medical Sciences, Associate Professor B. B. Dyusupova.
Professor L. K. Karazhanova founded the Nephrology School of East Kazakhstan and made significant contributions to the development of clinical cardiology, pulmonology, and endocrinology. She has published 12 monographs, over 1,000 scientific papers, holds 65 patents, 57 educational and methodological manuals, and is the chief editor of two books translated into the state language. Under her supervision, 6 doctoral, 35 candidate, and 6 master’s theses have been defended.
Her main research focus is on the molecular-genetic aspects of multifactorial diseases. For her contributions to science and education, she has been awarded state honors, research grants, and the title of Distinguished Professor of Semey Medical University.
Mayra Zhaksymanovna Espenbetova – Doctor of Medical Sciences, Professor, a leading endocrinologist of the Republic of Kazakhstan. For many years, she headed the Department of Endocrinology of Semey Medical University and is currently a Professor at the Department of Therapy and a practicing endocrinologist of the highest category. Her main research field is radiation thyroidology. She is the author of over 240 scientific papers, 8 monographs, 10 methodological guidelines, and 7 patents. Under her supervision, 10 candidate, 5 master’s, and 2 PhD theses were defended.
About the Department
The Department hosts the following scientific schools:
– “Scientific Basis for Improving Therapeutic, Diagnostic, and Preventive Care for Patients with Cardiological and Therapeutic Diseases”, led by Prof. L. K. Karazhanova, MD.
– “Clinical and Experimental Thyroidology”, led by Prof. M. Zh. Espenbetova, MD.
All instructors hold the highest qualification category, actively participate in research, integrate modern educational technologies into the learning process, and contribute significantly to the training of highly professional medical personnel. The department also conducts advanced training courses for healthcare professionals, aimed at improving professional knowledge and skills.
The department’s scientific activity continues to evolve: expanding the scope of research, strengthening interdisciplinary collaboration, and engaging residents in scientific projects to develop research competence and clinical thinking.
Teaching Staff
Dzhamilya Anvarovna Mansurova – Head of the Department, PhD, Associate Professor, cardiologist of the highest category, internist.
Aisulu Sarsengazievna Zhunuspekova – PhD, cardiologist and internist of the highest category. Actively engaged in research, author of over 30 publications, including 4 in Scopus-indexed journals, and 4 author’s certificates.
Mirgul Amangaliyevna Kapakova – Assistant Professor of the Department, Candidate of Medical Sciences, physician of the highest category in Internal Medicine and Cardiology. She defended her dissertation on the topic: “Pathogenetic features of myocardial infarction combined with cerebrovascular insufficiency and issues of treatment optimization.”She is responsible for the residency programs in the specialties “Therapy” and “Hematology (Adult).”She serves as a clinical mentor for internal medicine residents. Author of more than 50 scientific publications, 1 monograph, 6 teaching and methodological manuals, and 5 authorship certificates.
Andrey Yuryevich Orekhov – PhD, Assistant, cardiologist of the first qualification category. Author of over 30 scientific papers in peer-reviewed journals.
Alfiya Omirbekovna Aimagambetova – PhD, Assistant, cardiologist and internist of the highest category. Responsible for residency in “Adult and Pediatric Cardiology.” Defended her doctoral dissertation on “The Role of Cytokines and Cytokine Gene Polymorphism in ST-Elevation Myocardial Infarction.”
Saule Yuryevna Maimysheva – Internist of the highest category, PhD doctoral student in “Medicine,” author of about 10 scientific papers, including 3 in Scopus-indexed journals, and 4 author’s certificates.
Gulnara Sovetkalievna Sarsebayeva – Assistant, endocrinologist of the highest category. Conducts classes with 5th-year students, 6th-year general practice interns (module “Endocrinology”), and performs clinical work in the endocrinology department of the Emergency Hospital. Clinical mentor for endocrinology residents, member of the Endocrinologists Association of Kazakhstan, author of more than 10 scientific and educational works.
Other staff members: Saltanat Asanqyzy Asanova, Assel Alenovna Kasymova, Gulim Danabekqyzy Amantaeva, Madina Mirzhanovna Zekenova, Anar Dauletqyzy Kozhabayeva.
Department Goals
To train qualified and competitive specialists who meet modern standards and are capable of independent professional work in therapy.
Department Objectives
To improve the knowledge of undergraduate, internship, residency, and master’s students, and to provide them with a solid understanding, knowledge, and skills in therapeutic disciplines to ensure the healthcare system is supplied with qualified professionals capable of delivering medical care to both adults and children using modern diagnostic, preventive, treatment, and rehabilitation methods.
Clinical Bases
The clinical base of the Department of Therapy at Semey Medical University (SMU) is the Emergency Hospital of Semey, which includes three cardiology departments, an endocrinology department, an intensive care unit, and a radiology endovascular surgery unit.
The educational process is closely integrated with the clinical and diagnostic activities of the hospital. The department also uses the University Hospital (UH) of SMU, which includes cardiology and rheumatology departments, cardiovascular surgery, and an endovascular laboratory providing highly specialized care.
Residency training in cardiology at the Ust-Kamenogorsk branch of SMU is conducted at the East Kazakhstan Regional Hospital and Diagnostic Center (Consultative and Diagnostic Department).
The department’s clinical bases fully meet the requirements for training specialists — undergraduates, interns, and residents — who have full access to patients and are actively involved in the diagnostic and treatment process.


















